COVID-19 vaccines were dynamic protective, preventing millions of deaths. But in a small number of people, shots may have led to a constellation of side effects that include fatigue, exercise intolerance, brain fog, tinnitus and dizziness, which is referred to as “after vaccination syndrome”, according to a small new study.
Some people with this syndrome seem to have separate biological changes, research has found-among which differences in immune system cells, the rejuvenation of an inert virus called Epstein-Barr, and the persistence of a quarani protein in their blood.
The study was published online on Wednesday and has not yet been published in a scientific journal. “I would like to emphasize that this is still an ongoing project,” said Akiko Iwasaki, an immunologist at Yale University who led the project.
“It’s not like this study determines what makes people sick,” he said, “but it’s the first kind of look at what can happen to these people.”
Independent experts noted that the findings were not decisive in themselves. However, the results, from a scientific team known for strict work, suggest that after vaccination syndrome is worth further control, they said.
“One of the most important things is that we get some attention to really shine a light on it and try to figure out exactly what it is,” said John Wherry, Director of the Institute of Immunology at the University of Pennsylvania. (Dr. Wheerry has previously cooperated with Dr. Iwasaki’s team, but did not participate in this project.)
Thousands of people said the Covid vaccines hurt them. However, the fragmented United States healthcare system complicates the detection of unusual side effects and has given little clarity to the spectrum of symptoms that people may have experienced after a Covid Shot.
Patchwork has also been difficult to compare and concentrate self -reported jokes. The new study is small and the situation it is studying is “very heterogeneous”, said Dr. Gregory Poland, editor of Emeritus of the vaccine newspaper and president of the Atria Research Institute.
“Despite these limitations, they found interesting data that need further study,” he said. “Much larger studies of very carefully appointed and phenotypic people must be performed.”
Between December 2022 and November 2023, Dr. Iwasaki and her team collected blood samples from 42 people with after vaccination and 22 healthy people without it. People with the syndrome were generally in poorer health than the average American, according to researchers.
When the components of the immune system analyzed, people with after vaccination had different proportions of certain immune cells, compared to witnesses. It is not clear what these differences can mean. Researchers do not associate them with individual symptoms.
Because the symptoms reported by people with post -vaccination syndrome have a significant coating with those of Long Covid, the researchers also analyzed blood from 134 people with long Covid and 134 healthy witnesses.
Like people with long Covid, people with post-vaccination syndrome showed reactivation of the Epstein-Barr virus, a virus that may be inactive in the body and is associated with mononucleosis, hardening and other situations.
Some cases of long canned cans are considered to arise from the persistence of the Koran pins protein, resulting in an increased state of inflammation in the body.
Dr. Iwasaki and her team found that people with post-vaccination syndrome had significantly higher levels of plasma of the Koran Aks protein than everyone else-including those with long Covid-from 26 to 709 days after taking the vaccine.
Dr. Iwasaki said the mRNA vaccines were unlikely to be the source of the protein so long after the shooting was administered. “Something else allows this kind of expression of spike protein, and we don’t really know what this is,” he said.
Dr. WHERRY proposed attention to the interpretation of this result. For example, it is likely that some of the proteins may result from undetected infections of corona. “I would like to see more data on this issue,” he said.
He also added, the lack of clear answers makes it even more important to continue to investigate the issue.
“One of the things that scientists may have been trapped a little during the pandemic is this perception that we must have all the answers and if we cannot give it a definitive answer, then we should not talk about it,” he said.
“I think that’s a mistake,” he added. “We can’t say with certainty that this can’t happen.”
